I had no problem with discomfort or itchy eyes. From the first time I put them on, there was no problem to the wee hours..
My eyes were never dried out or itchy or event showed any sign of redness. They are just really comfortable to wear for an extended amount of hours of everyday. I didn't have to use any eye drops either. As long as you cleaned them thoroughly, you will be run into any problems with discomfort! I also wore makeup with these lenses and had ho problems applying things to my eyes.